Versel Lotion
Versel Lotion - General Information
Versel Lotion is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Versel Lotion is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.
Pharmacology of Versel Lotion
Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
Versel Lotion for patients
Versel Lotion Interactions
Versel Lotion Contraindications
Not to be used by patients allergic to ingredients.
Additional information about Versel Lotion
Versel Lotion Indication: For treatment of tinea versicolor, dandruff and seborrheic dermatitis of the scalp.
Mechanism Of Action: Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Selenium Sulfide
Synonyms: Selenium Disulfide; Selenium sulfide red powder; Selenium sulphide; Sulfur selenide; SeS
Drug Category: Antifungals for Topical Use
Drug Type: Small Molecule; Approved
Other Brand Names containing Selenium Sulfide: Exsel; Exsel Lotion Shampoo; Glo-Sel; Head & Shoulders Intensive Treatment 2 in 1 (Persistent Dandruff Shampoo plus Conditioner in One) Formula Dandruff Lotion Shampoo; Head & Shoulders Intensive Treatment Conditioning Formula Dandruff Lotion Shampoo; Head & Shoulders Intensive Treatment Regular Formula Dandruff Lotion Shampoo; Sebusan; Selenium(IV) sulfide; Selensulfid; Selsun; Selsun Blue; Selsun Blue Dry Formula; Selsun Blue Extra Conditioning Formula; Selsun Blue Extra Medicated Formula; Selsun Blue Oily Formula; Selsun Blue Regular Formula; Versel Lotion;
Absorption: There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
Toxicity (Overdose): No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Versel Lotion: Liquid Topical
Lotion Topical
Shampoo Topical
Chemical IUPAC Name: Not Available
Chemical Formula: SSe
Selenium Sulfide on Wikipedia: Not Available
Organisms Affected: Humans and other mammals; Fungi; Bacteria
